Maricopa Community Colleges  NMT235   19906-20032 
Official Course Description: MCCCD Approval: 04/22/03
NMT235 19906-20032 LEC 2 Credit(s) 2 Period(s)
Radiochemistry/Radiopharmacology I
Chemistry concepts as related to organic chemistry and biochemistry. Production, generator systems, short- and long-term radiopharmaceuticals utilized in radiochemistry. Principles of toxicity. Diagnostic and therapeutic radionuclides used in nuclear medicine imaging procedures. Localization techniques and kinetics of radiopharmaceuticals. Prerequisites: Admission to Nuclear Medicine Program, or permission of program director or department chair.
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MCCCD Official Course Competencies:
 
NMT235   19906-20032 Radiochemistry/Radiopharmacology I
1. State and define specific terminology related to basic chemistry concepts. (I)
2. Describe specific concepts related to organic chemistry. (II)
3. Describe specific concepts related to basic biochemistry. (III)
4. Describe production of the generator systems for specific short-lived and long-lived radionuclides. (IV)
5. Define toxicity, sterility, and pyrogenicity and differentiate acute, prolonged, and chronic toxicity tests. (V)
6. Describe diagnostic and therapeutic radiopharmaceuticals to include tissue affinity, half-life, radiation characteristics, patient dose and toxicity. (VI)
7. Explain principles of basic radiopharmaceutical chemistry to include activities, principles of equilibrium, and elution. (VII)
8. Explain the localization techniques and kinetics for radiopharmaceuticals. (VIII)
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MCCCD Official Course Outline:
 
NMT235   19906-20032 Radiochemistry/Radiopharmacology I
    I. Basic Chemistry Concepts
        A. Terminology
        B. Atomic number
        C. Gram molecular weight
        D. Avogadro's number
        E. Mole
        F. Specific gravity
        G. Units, measures, and symbols
        H. Periodic chart
        I. Chemical bonds
        J. Formulas and nomenclature
      II. Organic Chemistry
          A. Definitions
          B. Hydrocarbon structure
          C. Classification system
          D. Organic reactions
          E. Aromatic compounds
        III. Biochemistry
            A. Definitions
            B. Proteins
            C. Carbohydrates
            D. Enzymes
            E. Vitamins
            F. Hormones
          IV. Radionuclides
              A. Production
              B. Generator systems
              C. Activity
                1. Growth and decay
                2. Activity calculations
              D. Short-lived radionuclides
                1. Tc-99m
                2. I-123
                3. In-111 and -113m
                4. F-18
                5. Xe-133
                6. Hg-197
                7. Au-198
                8. Kr-81m
              E. Long-lived radionuclides
                1. I-131 and -125
                2. 5e-75
                3. Cr-51
                4. CO-57
                5. p-32
                6. Ga-67
                7. T1-201
                8. Yb-169
                9. Fe-59
                10. CO-58
            V. Tests
                A. Toxicity
                B. Sterility
                C. Pyrogenicity
                D. Acute toxicity tests
                E. Prolonged toxicity tests
                F. Chronic toxicity tests
              VI. Radiopharmaceuticals
                  A. Diagnostic agent
                    1. Tissue affinity
                    2. Half-life
                    3. Radiation characteristics
                    4. Patient dose
                    5. Toxicity
                  B. Therapeutic agent
                    1. Tissue affinity
                    2. Half-life
                    3. Radiation characteristics
                    4. Patient dose
                    5. Toxicity
                VII. Radiochemistry
                    A. Activities
                      1. Growth and decay
                      2. Activity calculation
                    B. Principles of equilibrium
                      1. Parent-daughter equilibrium
                      2. Secular and transient equilibrium
                    C. Elution
                  VIII. Radiopharmaceutical Localization
                      A. Dilution
                      B. Diffusion
                      C. Active transport
                      D. Metabolic incorporation
                      E. Phagocytosis
                      F. Cell sequestration
                      G. Capillary blockage
                      H. Kinetics
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