MCCCD Official Course Competencies:

RES134  2007 Fall – 2009 Summer II

Advanced Respiratory Care Pharmacology

1.

Review basic pharmacologic principles. (I)

2.

Given a patient with bronchial smooth muscle abnormality, identify appropriate pharmacological agents. (II)

3.

Given a patient with respiratory infection, identify appropriate antimicrobial therapy. (III)

4.

Administer topical anesthetics. (IV)

5.

Describe the non respiratory drugs which effect ventilation. (V)

MCCCD Official Course Outline:

RES134  2007 Fall – 2009 Summer II

Advanced Respiratory Care Pharmacology

I. Pharmacologic Principles

A. Competitive antagonism

B. Noncompetitive antagonism

C. Absorption and degradation

II. Bronchial Smooth Muscle Abnormality

A. Review of autonomic nervous system

1. sympathetic

2. parasympathetic

B. Adrenergic receptors and Amines

1. chemistry

2. alpha and beta activity

3. receptor selectivity

C. Muscarinic Antagonists

1. action

2. rationale

3. diagnostic use

D. Airway mediators

1. histamine

a. synthesis, release, and metabolism

b. action

c. release during allergic response

d. diagnostic use

e. agents used for protection against histamine induced reversible airway disease

2. Prostaglandins

a. chemistry, synthesis, and inactivation

b. effects in the lungs

c. factors governing release in the lung

d. prostaglandins as therapeutic agents

3. Leukotrienes

4. Antiasthmatics

E. Bronchodilators

1. sympathomimetics

2. parasympatholytic

3. xanthines

F. Corticosteroids

1. structure and metabolism

2. mechanics of action

3. adverse effects

4. administration

III. Antimicrobial Agents

A. Principles

1. antimicrobial therapy

2. identification of pathogens

3. modes of action

4. microbial resistance

5. superinfections

6. routes of administration

B. Treatment of Pulmonary Infections

1. penicillins

2. cephalosporins

3. aminoglcosides

4. tetracyclines

5. sulfonamides

6. chloramphenicol

7. polymyxin B

8. erythromycin

9. clindamycin

10. antifungal

11. antituberculosis

IV. Topical Anesthetics

A. Dosage

B. Side effects

V. Non Respiratory Drugs which affect Ventilation

A. Neuromuscular blocking agents

1. nondepolarizing

2. depolarizing

B. Diuretics

1. action

2. effects

3. therapeutic uses

4. types

C. Agents affecting the central nervous system

1. central nervous system

2. narcotics and non narcotics

3. narcotics antagonists

4. sedative/hypnotics

5. antipsychotic tranquilizers

D. Respiratory stimulants

E. Agents affecting the Cardiovascular system

1. inotrophic

2. antiarrythmic

3. antianginal

4. calcium- channel blockers

5. beta blockers

6. alpha agonists

7. angiotensin converting enzymes

8. drugs affecting the blood

a. anticoagulants

b. thrombolytics

c. others

F. Insulin