MCCCD Official Course Competencies:

DMI215  1999 Fall – 2009 Spring

Radiation Biology

1.

Describe the characteristics and forms of specific types of radiation. (I)

2.

Explain select principles of radiobiology to include physical and biologic factors affecting radiosensitivity. (II)

3.

Describe principles and factors related to molecular and cellular radiobiology. (III)

4.

Explain the early effects of radiation on select tissues and organ systems. (IV)

5.

Explain the late effects of radiation on select tissues, organ systems, and increased risk of malignancy. (V)

6.

Describe the risks associated with radiation exposure of the fetus. (V)

MCCCD Official Course Outline:

DMI215  1999 Fall – 2009 Spring

Radiation Biology

I. Types of Radiation

A. Interactions with matter

B. Electromagnetic

C. Particulate

D. Ionizing and non-ionizing

E. Sources of medical exposure

II. Principles of Radiobiology

A. Human biology

B. Law of Bergonie' and Tribondeau

C. Physical factors affecting radiosensitivity

D. Biologic factors affecting radiosensitivity

E. Radiation dose-response relationships

III. Molecular and Cellular Radiobiology

A. Irradiation of macromolecules

B. Radiolysis of water

C. Direct and indirect effects

D. Target theory

E. Cell survival kinetics

F. Linear energy transfer (LET)

G. Relative biological effectiveness (RBE)

H. Oxygen enhancement ratio (OER)

IV. Early Effects of Radiation

A. Acute radiation lethality

B. Local tissue damage

C. Hematological effects

D. Cytogenetic effects

V. Late Effects of Radiation

A. Local tissue effects

B. Life span shortening

C. Risk estimates

D. Radiation-induced malignancy

E. Total risk of malignancy

F. Radiation and pregnancy