Maricopa Community Colleges  DMI268   19986-20035 
Official Course Description: MCCCD Approval: 05/26/98
DMI268 19986-20035 LEC 3 Credit(s) 3 Period(s)
NUCLEAR IMAGING THEORY II
Chemistry concepts related to organic chemistry and biochemistry. Radioactive materials production and generator systems, short- and long-term radiopharmaceuticals utilized in radiochemistry. Principles of toxicity. Diagnostic and therapeutic radionuclides used in nuclear medicine imaging procedures. Localization techniques and kinetics of radiopharmaceuticals. Choice of pharmaceutical by organ system. Radiopharmaceutical preparation, storage, labeling, and record keeping. Description of federal and state agencies governing the use of radiopharmaceuticals. Survey of radiopharmaceuticals utilized in therapeutic procedures. Quality control techniques for pharmaceutical production. Prerequisites: DMI260 or permission of program director.
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MCCCD Official Course Competencies:
 
DMI268   19986-20035 NUCLEAR IMAGING THEORY II
1. Describe specific terminology and concepts related to related to basic, organix, and bio- chemistry. (I, II, III)
2. Describe production of the generator systems for specific short-lived and long-lived radionuclides. (IV)
3. Define toxicity, sterility, and pyrogenicity and differentiate acute, prolonged, and chronic toxicity tests. (V)
4. Describe diagnostic and therapeutic radiopharmaceuticals to include tissue affinity, half-life, radiation characteristics, patient dose and toxicity. (VI)
5. Explain principles of basic radiopharmaceutical chemistry to include activities, principles of equilibrium, and elution. (VII)
6. Explain the localization techniques and kinetics for radiopharmaceuticals. (VIII)
7. Explain the accepted choice of pharmaceutical by organ system. (IX)
8. Describe specific methods for the preparation, storage, labeling, disposal, and record keeping of radiopharmaceuticals used in nuclear medicine procedures. (X)
9. List and describe the function and responsibilities of federal and state agencies governing the use of radiopharmaceuticals used in nuclear medicine. (XI)
10. Explain the preparation, quality control, storage, application, and disposal of radiopharmaceuticals used in therapeutic procedures. (XII)
11. Explain the calculation of patient dose, retention levels, and excretion rates for therapeutic radiopharmaceuticals. (XIII)
12. Describe radiation safety practices in the preparation, administration and disposal of radiopharmaceuticals. (XIV)
13. Explain the quality control concerns for radiopharmaceutical production and preparation. (XV)
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MCCCD Official Course Outline:
 
DMI268   19986-20035 NUCLEAR IMAGING THEORY II
    I. Chemistry
        A. Terminology
        B. Atomic number
        C. Gram molecular weight
        D. Avogadro's number
        E. Mole
        F. Specific gravity
        G. Units, measures, and symbols
        H. Periodic chart
        I. Chemical bonds
        J. Formulas and nomenclature
      II. Organic Chemistry
          A. Definitions
          B. Hydrocarbon structure
          C. Classification system
          D. Organic reactions
          E. Aromatic compounds
        III. Biochemistry
            A. Definitions
            B. Proteins
            C. Carbohydrates
            D. Enzymes
            E. Vitamins
            F. Hormones
          IV. Radionuclides
              A. Production
              B. Generator systems
              C. Activity
                1. growth and decay
                2. activity calculations
              D. Short-lived radionuclides
                1. Tc-99m
                2. I-123
                3. In-111 and -113m
                4. F-18
                5. Xe-133
                6. Hg-197
                7. Au-198
                8. Kr-81m
              E. Long-lived radionuclides
                1. I-131 and -125
                2. Se-75
                3. Cr-51
                4. CO-57
                5. P-32
                6. Ga-67
                7. T1-201
                8. Yb-169
                9. Fe-59
                10. CO-58
            V. Tests
                A. Toxicity
                B. Sterility
                C. Pyrogenicity
                D. Acute toxicity tests
                E. Prolonged toxicity tests
                F. Chronic toxicity tests
              VI. Radiopharmaceuticals
                  A. Diagnostic agent
                    1. tissue affinity
                    2. half-life
                    3. radiation characteristics
                    4. patient dose
                    5. toxicity
                  B. Therapeutic agent
                    1. tissue affinity
                    2. half-life
                    3. radiation characteristics
                    4. patient dose
                    5. toxicity
                VII. Radiochemistry
                    A. Activities
                      1. growth and decay
                      2. activity calculation
                    B. Principles of equilibrium
                      1. parent-daughter equilibrium
                      2. secular and transient equilibrium
                    C. Elution
                  VIII. Radiopharmaceutical Localization
                      A. Dilution
                      B. Diffusion
                      C. Active transport
                      D. Metabolic incorporation
                      E. Phagocytosis
                      F. Cell sequestration
                      G. Capillary blockage
                      H. Kinetics
                    IX. Choice of Radiopharmaceutical
                        A. General considerations
                        B. Special considerations
                        C. Organ system
                      X. Radiopharmaceuticals
                          A. Preparation
                            1. commercial preparations
                            2. kit preparations
                            3. particle sizing
                            4. chromatography and separation techniques
                            5. methods of analysis
                            6. biological controls
                          B. Storage
                            1. radiopharmaceuticals
                            2. specimens
                          C. Labeling
                          D. Disposal
                            1. radiopharmaceuticals
                            2. specimens
                          E. Record keeping
                            1. radiopharmaceuticals
                            2. equipment
                            3. personnel
                            4. patients
                        XI. Regulations and Certification
                            A. Federal
                              1. nuclear regulatory commission (N.R.C.)
                              2. food and drug administration (F.D.A.)
                              3. department of transportation (D.O.T.)
                            B. State
                              1. agreement state regulations
                              2. institutional regulations
                            C. Technologist certification
                          XII. Therapeutic Radiopharmaceuticals
                              A. Preparation
                              B. Quality control
                              C. Storage
                              D. Application
                              E. Disposal
                            XIII. Therapeutic Radiopharmaceutical Calculations
                                A. Patient dose
                                B. Retention levels
                                C. Excretion rates
                              XIV. Radiation Safety
                                  A. Preparation
                                  B. Administration
                                  C. Disposal
                                XV. Quality Assurance
                                    A. Purity testing
                                    B. Sterility
                                    C. Pyrogenicity
                                    D. pH
                                    E. Particle size
                                    F. Color and clarity
                                    G. Toxicity
                                    H. Stability
                                    I. Kit techniques and procedures
                                    J. Chromatography
                                    K. Generator quality control
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