Maricopa Community Colleges  BIO241   19962-19976 
Official Course Description: MCCCD Approval: 12/12/95
BIO241 19962-19976 LEC 3 Credit(s) 3 Period(s)
Human Genetics
An introduction to the basic concepts of human heredity and cytogenetics including Mendelian, molecular, and population genetics. Prerequisites: BIO100, or BIO181, or equivalent, or permission of instructor.
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MCCCD Official Course Competencies:
 
BIO241   19962-19976 Human Genetics
1. Explain the major contributions to the development of human genetics. (I)
2. Define terms used in human genetics. (II)
3. Distinguish between the major modes of monogenic inheritance. (III)
4. Explain the mechanics of cell division. (IV)
5. Explain the biochemical nature of genes and chromosomes. (IV)
6. Explain how numerical and structural chromosome abnormalities arise. (IV)
7. Describe the nature and causes of mutation. (IV)
8. Explain the basic tenets of multigenic inheritance. (V)
9. Explain the underlying principles of population genetics. (VI)
10. Explain the importance of prenatal diagnostic techniques in genetic counseling. (VII)
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MCCCD Official Course Outline:
 
BIO241   19962-19976 Human Genetics
    I. History of the development of human genetics
      II. Terminology of human genetics
        III. Principles of Mendelian genetics
            A. Autosomal recessive
            B. Autosomal dominant
            C. X-linked recessive
            D. X-linked dominant
            E. Y-linked
          IV. Chromosomes and genes
              A. Physical basis of inheritance
              B. Chemical nature of genes and chromosomes
              C. Mitosis
              D. Meiosis
              E. Gene mapping
              F. Expression of genes and regulation of expression
              G. Numerical chromosomal abnormalities
              H. Structural chromosomal abnormalities
              I. Mutation
              J. Karyotyping
              K. Biochemical genetics
                1. Metabolic disorders
                2. Amnicentesis - screening for enzymes
              L. Genetics of the immune system
                1. Blood groups
                2. Histocompatibility
                3. Antibody formation
                4. Autoimmune disorders
            V. Polygenic traits
              VI. Genes in populations
                  A. Gene frequencies
                  B. Genotype frequencies
                  C. Calculation of gene frequencies
                  D. Hardy-Weinburg equilibrium
                  E. Genetic drift
                  F. Founder effect
                  G. Evolution
                VII. Availability of prenatal diagnostic techniques
                    A. Amniocentesis
                    B. Chorionic villi analysis
                    C. Use of DNA probes
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